Neutrophil Function in Health and Disease

Neutrophils are the most abundant kind of granulocytes and white blood cells in humans. They are an integral part of the innate immune system. Neutrophils are the first inflammatory cells to migrate to a site of injury following trauma. Often they require assistance from other types of immune cells in order to resolve certain infections. The cytokines expressed by activated mast cells, endothelium and macrophages cause neutrophils to congregate at a focus of infection. These neutrophils release cytokines which amplify the inflammatory responses generated by other cells. Through the processes of degranulation, phagocytosis and generation of neutrophil extracellular traps, neutrophils directly attack the invading pathogens. Neutropenia or low neutrophil count makes an individual susceptible to infections. Abnormal neutrophil function leads to excessive tissue damage, disruption of pulmonary barrier, hyperglycemia, etc. This book provides comprehensive insights into the clinical frontiers and functions of neutrophils in health and disease. It will also provide interesting topics for research, which interested readers can take up. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.