Evil creatures called Nemeses fall from the skies and the only ones who can fight them are Wizards--infected ones who survived a Nemesis's corruption. Seth, one of these survivors, vows not only to fight the Nemeses, but to find their mythical nest, Radiant, and destroy it!

The mysterious Grimm is ready to hand Seth over to his enemies, the Domitors, but this plan gets kicked to the curb with the arrival of one of Seth's brothers, Piodon, who demonstrates startling power. Seth's friends Doc and Ocoho, meanwhile, are searching for Mélie, another of Seth's friends, who's gone very strange of late. In addition, Ocoho has been saddled with two problematic allies: a headstrong former Domitor named Lupa and Diabal, Seth's older brother, a wizard teetering on the edge of losing his mind!