On the day of his last medical school exam, Danny Benson receives a Dear John letter from his fiancé Heather. In it, she writes that the engagement is off. Why? She's flown to London to meet up with her friends and ride the Magic Bus, traveling overland to Kathmandu Nepal. The postmark is dated two weeks earlier.

With his plans shattered and a sudden urgency, Danny instinctively knows what he has to do: set out on a journey thousands of miles from home in search of her. Just one last conversation stands in the way of either rekindling their relationship or get the closure to move on with his life.

When he inexplicably runs into Heather crossing continents, they spend the entire ride debating whether to stay together or break up forever. Arriving in town and exhausted from their long bus trip and long-drawn-out conversation, fate decides for them. Instead of resolution, their decisive moment materializes when they collide with history.