Five animals, four cats and a dog, are all black and white and are females, but they have two more things in common not apparent at first - they have all been treated badly in different ways by a number of humans and they all have a superpower which helps them to get away from the baddies. Two kind brothers, nine-year-old Diarmuid and seven-year-old Eoghan, rescue the cats Smig, Ebi, Trig and Róisín and the dog, Mags, and persuade their parents to take them all into their home.
The animals do not like each other at first, but eventually Mags persuades the cats to abandon their differences and unite together to form The She Team. Her encouraging words, "Don't get mad, get even!" convince them that they will work together to stop their tormentors from hurting other animals. They are confident that their superpowers will help them achieve their goal.