Ant Roy The Bug Boy tells the story of three close school friends who experience the torment and bewilderment of being bullied by a boy in their class and his best buddy. This somewhat nerdy group of friends decide to solve the mystery of the bully, why is he the way he is, why isn't he nicer and more friendly, even though they try so hard to get along with him?

They discover that Bradley, the bully, has a little brother with multiple sclerosis. His parents have recently divorced, forcing Bradley, his mother and brother to move in with his grandparents. As the group finds out more about him, Bradley finally opens up and tells of his feelings of loneliness and unhappiness. The friends are compassionate, they know they can help him, and decide to open their group to include the bully and his buddy. Bradley is relieved and grateful to finally be understood, and all become friends.

The class gives oral reports on subjects they know best; Roy's specialty is insects, especially ants, and Bradley's is nerve diseases, since he knows a lot about multiple sclerosis. These subjects that had brought Roy, the nerd, and Bradley the bully, so much ridicule and sensitivity before ultimately turn out to be strong subjects for oral reports, capturing the other students' and teacher's interest and acclaim.