This book takes up the question, "What can we know?" or, even deeper, "Do we know anything at all?" The true skeptic cannot begin with any assumptions of knowledge. In the first chapter, this book takes doubt to a radical level, echoing the purpose of Rene Descartes' famous, but widely criticized, Meditations. The author takes up the epistemological debate, throwing down popular notions of foundationalism and coherentism alike, and declares all knowledge suspect until at least one shred of evidence can be called, truly, undoubtable.

After this "grueling duel with doubt" the author enters into an exploration of this true knowledge, and its implications for large philosophic discussions--such as "What is reality?", metaphysics, and morality--and everyday life--"How do we live these conclusions" and, "What can these new outlooks do for us?". From the beginning of the book, the author the author challenges Vincent Bugliosi's work Divinity of Doubt, and offers answers to many of the arguments and questions therein. Overall, in addition to rewriting epistemology, metaphysics and the like, the author's intention is to defend an intelligent view of religion which is in line with modern scientific thought and discovery.